Medical Moment Recent Study on Insulin Resistance and AIP

A recent mouse model study, High Prevalence of Insulin Resistance in Asymptomatic Patients with Acute Intermittent Porphyria and Liver-Targeted Insulin as a Novel Therapeutic Approach, published in Biomedicine has found a high instance of insulin resistance among patients with Acute Intermittent Porphyria (AIP). The study Investigators reported “that [insulin resistance] and high-serum insulin levels are not a consequence of disease activity, but rather that sustained hyperinsulinemia can protect against acute attacks of porphyria.”

Insulin resistance occurs when cells do not respond to insulin and can't process blood glucose into energy. Therefor, finding a more effective form of insulin delivery in the liver may improve the effects of glucose therapy for preventing acute attacks.

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